• facing the mismatch between structural and mechanical properties of chondral lesions
  • addressing gaps between structural and mechanical properties of chondral lesions
  • engineering solutions for complex lesion geometry and dimension
  • challenging cartilaginous metabolism
  • overcoming undesired biological events during regeneration

Instituto Nacional de Engenharia Biomédica is a non-profit association with the statute of public interest that aims to generate knowledge, promoting research, advanced training and technology transfer. In RESTORE, INEB is project coordinator, being responsible for coordination and management activities, as well as to integrate the nanoenabled 3D matrix based on the COPLA® Scaffold.

University of Oulu is an academic organization recognized by its high-quality and international research environment. Microelectronics Research Unit brings the expertise of the applicability of nanomaterials for cell engineering, while the Medical Imaging, Physics and Technologies Research Unit has extensive experience in the methods development for clinical diagnostic of osteoarticular diseases.

The Institute of Orthopaedic Research and Biomechanics at Ulm University Medical Centre investigates the musculoskeletal system. The joint biomechanics group focusses on the functional restoration after meniscus and cartilage lesions. In RESTORE we will biomechanically characterize cartilage scaffolds and are responsible for preclinical testing.

The Institute of Biomedical and Neural Engineering (in Reykjavik University), aims to coordinate large-scale, multi-disciplinary research initiatives between universities, Hospital and Med-Tech companies. In RESTORE, we will build a database (clDB) of patient-specific anatomical models of different chondral.

CIDETEC develops cutting-edge technology to transform it into advanced products. Our mission in RESTORE is to design and produce drug delivery systems based on biocompatible nanoparticles and nanoemulsions for a tricombinatorial drug delivery.

University of Gothenburg (UGOT) has extensive experience in reprogramming and rejuvenation of cells into stem cells. has the know-how and the facilities for 3D bioprinting of cartilage and is responsible for 3D bioprinting microtissues within RESTORE.

SINTEF is a non-profit independent research organization performing contract research for industry and participating in publicly funded projects. The Biotechnology and Nanomedicine department contributes in RESTORE with safety aspects and regulatory issues, physicochemical characterisation and in vitro cytotoxicity and antimicrobial efficacy studies .

The Department of Health Sciences at UPO is devoted to produce knowledge on the key aspects for human health and transform it into enable technologies. In RESTORE, UPO contributes to develop and characterize the anti-infective and immune-compatible devices.

Askel Healthcare Ltd is a Finnish start-up focusing on medical devices for cartilage tissue regeneration. In RESTORE Askel is assisting other partners in the combination of nanomaterials into their COPLA® Scaffold, a medical device designed for cartilage repair.

3DTech Oy is a Finnish SME specialized in 3D printing. We are developing our own 3D bioprinter, Brinter™, for the medical and pharmaceutical research and industry. In RESTORE, our role is to improve the performance of the cartilage bioprinting process by integrating novel features into our bioprinting platform.