Nanoenabled 3D matrices for mild and severe chondral lesions

Chondral lesions can possess complex geometry and dimensions, and the larger the defect, the higher the biomechanical requirements, presenting several lesion-specific factors to be considered by a medical professional when selecting the adequate treatment modality.
RESTORE is taking a lesion-specific approach, creating smart 3D matrices targeting mild and severe chondral lesions, designed to adjust to the defect dimensions and biomechanical load requirements.
RESTORE is accomplishing this in a two-front strategy: 3D cartilage microtissues engineered via 3D bioprinting (mild lesions), and COPLA® Scaffold (severe lesions).

These 3D matrices will be integrated with nanocarriers and/or stimuli-responsive nanobiomaterials able to mitigate illicit biological responses for an effective therapeutic repair of the articular cartilage defect.

Besides the effective therapeutic repair of the articular cartilage lesion, compared to current methods, these solutions will reduce the post-surgery recovery time.
For mild lesions, RESTORE’s nanoenabled bioprinted human cartilage will be able to fit to the individual lesion requirements such as geometry and shape.

For severe lesions with larger size and higher mechanical demands, the COPLA® Scaffold – currently commercialised in veterinary medicine as a solution for cartilage repair in weight-bearing joints with a high load regime – is being nano functionalised with RESTORE’s nanobiomaterials. This nanoenabled COPLA® Scaffold will respond to the high mechanical demands of these lesions and prevent undesirable biological responses.