These 3D matrices will be integrated with nanocarriers and/or stimuli-responsive nanobiomaterials able to mitigate illicit biological responses for an effective therapeutic repair of the articular cartilage defect.
Besides the effective therapeutic repair of the articular cartilage lesion, compared to current methods, these solutions will reduce the post-surgery recovery time.
For mild lesions, RESTORE’s nanoenabled bioprinted human cartilage will be able to fit to the individual lesion requirements such as geometry and shape.
For severe lesions with larger size and higher mechanical demands, the COPLA® Scaffold – currently commercialised in veterinary medicine as a solution for cartilage repair in weight-bearing joints with a high load regime – is being nano functionalised with RESTORE’s nanobiomaterials. This nanoenabled COPLA® Scaffold will respond to the high mechanical demands of these lesions and prevent undesirable biological responses.