User-centred smart nanobiomaterial-based 3D matrices for chondral repair
With patient wellbeing in mind, we are producing solutions for personalised cartilage regeneration, thus also meeting the needs of orthopaedic surgeons and generating reliable and reproducible data for regulatory bodies.
Articular cartilage is avascular and distinct in its weight-bearing and low-friction capabilities, lacking the capacity to regenerate. Conventional and current solutions (allografts, autografts and marrow stimulation) are not capable of providing cost-effective regeneration of cartilage tissue. Challenges when facing these lesions are (1) a mismatch between structural and mechanical properties, (2) the complex geometry/dimension, (3) enhanced cartilaginous metabolism, and (4) undesired biological events – inflammation, proteolytic degradation, and bacterial infection.
The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions
RESTORE’s goal is to develop and validate in pre-clinical animal models, nanoenabled solutions for personalised cartilage regeneration. Different strategies will be undertaken to overcome the current challenges and unmet clinical necessities, in order to design the most efficient solution towards cartilage repair. RESTORE shall have long raging benefits, holding high commercial promise for industries, creating new reliable and reproducible data for regulatory bodies, yearning to meet the need of orthopaedic surgeons in order to assure patients wellbeing and active ageing.
LEADING EDGE OF CARTILAGE REGENERATION
The RESTORE concept is to realize a new generation of smart 3D matrices for chondral lesions treatments. Key cutting-edge technologies will be employed into biocompatible 3D matrices to promote cartilage repair.