Why is RESTORE needed?
Chondral lesions constitute one of the major extrinsic risk factors for Osteoarthritis (OA) leading to important societal and economic burden. OA is a highly prevalent condition that can result in disabling pain and loss of physical function. Furthermore, increase competitiveness in sports activities increases the incidence of chondral injuries in athletes, which in turn propels the demand for cartilage repair products. RESTORE proposes innovative stimuli-responsive nanoenabled 3D matrices for an effective therapeutic repair of defects in articular cartilage.
Who are we?
The RESTORE Project is built upon constructive discussions between orthopaedic surgeons, tissue-engineers, material scientists, cell biologists, small and medium-sized enterprises (SMEs) to co-design an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. Ten partners from seven countries (Portugal, Spain, Italy, Germany, Sweden, Norway, Iceland and Finland), including Research and Technological Development institutes and two small-medium sized enterprises.
Future Impacts of RESTORE
- Tailored nanocarriers based on polymeric nanobiomaterials capable of mitigate illicit biological responses.
- Stimuli responsive nanobiomaterials tuned to external physical stimuli
- Nanoenabled 3D matrices for efficient chondral lesion repair
- Portable Medical Device for external stimulus and monitor cartilage regeneration
- 3D bioprinting technology advances
- Database of patient-specific anatomical models for condyle lesions
- Regulatory aspects of smart nanobiomaterials (reliable data on nanosafety)