RESTORE
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SEVE
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LESI
ONS

Full thickness defects or Severe cartilage injuries – macroscopic observation shows a complete erosion of the cartilage, leaving the underlying bone exposed in small or widespread areas. In these injuries, stem cells derived from the bone marrow, not from the cartilage, can form a fibrocartilaginous tissue to compensate the loss, but are also associated with increased pain, limitation in activity and structural changes that lead to knee osteoarthritis.

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